Detalhe da pesquisa
1.
Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents.
Bioorg Med Chem Lett
; 29(8): 1023-1029, 2019 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30773430
2.
A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB.
Protein Expr Purif
; 132: 75-84, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28137655
3.
A novel small-molecule MRCK inhibitor blocks cancer cell invasion.
Cell Commun Signal
; 12: 54, 2014 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25288205
4.
Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.
Bioorg Med Chem
; 20(22): 6770-89, 2012 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23018093
5.
Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.
J Med Chem
; 64(15): 11148-11168, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34342224
6.
NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models.
Breast Cancer Res
; 10(2): R33, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18430202
7.
4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.
J Med Chem
; 51(2): 196-218, 2008 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18020435
8.
Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.
Mol Cancer Ther
; 6(4): 1198-211, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17431102
9.
Accepting from the best donor; analysis of long-lifetime donor fluorescent protein pairings to optimise dynamic FLIM-based FRET experiments.
PLoS One
; 13(1): e0183585, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29293509
10.
A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma.
Cancer Res
; 78(22): 6509-6522, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30279244
11.
Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress.
Cancer Discov
; 8(5): 632-647, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29500295
12.
Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer.
Cancer Res
; 78(8): 2096-2114, 2018 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29382705
13.
Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors.
Mol Cancer Ther
; 5(6): 1628-37, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16818523
14.
Targeting Hsp90 for the treatment of cancer.
Curr Opin Drug Discov Devel
; 9(4): 483-95, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16889231
15.
Discovery and development of pyrazole-scaffold Hsp90 inhibitors.
Curr Top Med Chem
; 6(11): 1193-203, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16842156
16.
Rational design of inhibitors of HIV-1 TAR RNA through the stabilisation of electrostatic "hot spots".
J Mol Biol
; 336(2): 343-56, 2004 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-14757049
17.
Structure-based drug design targeting an inactive RNA conformation: exploiting the flexibility of HIV-1 TAR RNA.
J Mol Biol
; 336(3): 625-38, 2004 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-15095977
18.
Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.
J Med Chem
; 48(13): 4212-5, 2005 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15974572
19.
Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms.
Chem Biol
; 11(6): 775-85, 2004 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15217611
20.
Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks.
Neoplasia
; 17(9): 704-715, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26476078